Nicotinamide-substituted complexes as redox markers. 2. Synthesis of a 99Tc-dihydropyridine mixed-ligand complex and investigation of the stability in tissue homogenates


Nicotinamide-substituted complexes as redox markers. 2. Synthesis of a 99Tc-dihydropyridine mixed-ligand complex and investigation of the stability in tissue homogenates

Rother, A.; Kniess, T.; Pütz, M.; Jungclas, H.; Spies, H.; Johannsen, B.

For developing a dihydropyridine/pyridinium salt redox delivery system that could be useful for SPECT investigations by 99mTc compounds the synthesis of a mixed-ligand complex of the long-lived isotope 99Tc is described. The new compound bearing a pyridinium salt moiety was characterised by NMR-spectrometry and X-ray structure analysis. By reduction with sodium dithionite the corresponding 1,4-dihydropyridine complex was prepared and the stability in buffer, tissue homogenates, blood plasma and cerebrospinal fluid was investigated by UV-VIS spectrometry.

Keywords: redox delivery system; pyridinium salt; 1,4-dihydropyridine

  • Journal of Labelled Compounds and Radiopharmaceuticals 42, 673-681(1999)

Permalink: https://www.hzdr.de/publications/Publ-2093
Publ.-Id: 2093