Stability Studies on 99mTechnetium(III) Complexes with Tridentate/Monodentate Thiol Ligands and Phosphine ("3+1+1" Complexes)


Stability Studies on 99mTechnetium(III) Complexes with Tridentate/Monodentate Thiol Ligands and Phosphine ("3+1+1" Complexes)

Seifert, S.; Drews, A.; Gupta, A.; Pietzsch, H.-J.; Spies, H.; Johannsen, B.

The preparation and characterisation of "3+1+1" technetium complexes of the gen-eral formula [Tc(SES)(RS)(PMe2Ph)] (SES = tridentate dithiol ligand, E = S, O, NMe; RSH = monothiol ligand) at the no carrier added level is described. The Tc(III) com-plexes are prepared in a one-step procedure starting from pertechnetate in yields of 85 - 95 % of radiochemical purity. A comparison of their chromatographic data with the fully characterised 99Tc complexes indicate the identity of the investigated com-pounds. Stability studies show that the 99mTc complexes undergo some alteration in solution. They are oxidised to the 3+1 oxotechnetium(V) complexes and/or decom-pose in aqueous solution. In challenge experiments performed with glutathione, ex-change of the monothiolato ligand occurs in the same manner as known for the 3+1 complexes.

Keywords: 3+1+1 99mTc complexes; preparation; stability

  • Appl. Radiat. Isot. 53 (2000) 431-438

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Publ.-Id: 2101