Interaction of Eu(III) and Cm(III) with mucin – a key component of the human mucosa


Interaction of Eu(III) and Cm(III) with mucin – a key component of the human mucosa

Wilke, C.; Raff, J.; Barkleit, A.; Ikeda-Ohno, A.; Stumpf, T.

Lanthanides (Ln) and actinides (An) could potentially be chemo- and radiotoxic when they are incorporated into the food chain after accidental releases to the environment. This spectroscopic study focuses on the interaction of Ln(III) and An(III) with mucin, one of the essential components of human mucosa, for better understanding of their behaviour in human gastrointestinal tract in case of oral ingestion. The first spectroscopic screening with TRLFS (Time-Resolved Laser-Induced Fluorescence Spectroscopy) revealed mucin as a fundamental binding partner of Eu(III) as well as of Cm(III) in the human gastrointestinal tract. Mucin is an important glycoprotein of the mucosa, working as an important protective barrier on the digestive system and functions. Mucin can interact with metal ions via a variety of their saccharides. This contribution is dedicated to the identification of dominant binding groups of Mucin with Ln(III) and An(III) by spectroscopy (TRLFS, IR, NMR) and thermodynamic calculations

Keywords: lanthanides; actinides; Eu(III); Cm(III); TRLFS; spectroscopy; mucin

  • Contribution to proceedings
    Goldschmidt, 26.06.-01.07.2016, Yokohama, Japan
  • Lecture (Conference)
    Goldschmidt, 26.06.-01.07.2016, Yokohama, Japan

Permalink: https://www.hzdr.de/publications/Publ-23430
Publ.-Id: 23430