Translation of a prompt gamma based proton range verification system to first clinical application


Translation of a prompt gamma based proton range verification system to first clinical application

Richter, C.; Pausch, G.; Barczyk, S.; Priegnitz, M.; Golnik, G.; Bombelli, L.; Enghardt, W.; Fiedler, F.; Fiorini, C.; Hotoiu, L.; Janssens, G.; Keitz, I.; Mein, S.; Perali, I.; Prieels, D.; Smeets, J.; Thiele, J.; Vander Stappen, F.; Werner, T.; Baumann, M.

To improve precision of particle therapy, in vivo range verification is highly desirable to reduce range uncertainties and thereby increase the advantage of proton therapy. Methods based on prompt gamma rays emitted during treatment seem promising but have not yet been applied clinically, although proposed 12 years ago. We report on the translational implementation as well as the worldwide first clinical application of prompt gamma imaging (PGI) based range verification. A prototype of a PGI camera was used to measure the prompt gamma depth distribution during proton treatment of a head and neck tumor. Inter-fractional variations of the prompt gamma profile were evaluated and anatomical changes were independently verified.

  • Lecture (Conference)
    ESTRO 35, European society for radiotherapy and oncology, 29.04.-03.05.2016, Turin, Italy

Permalink: https://www.hzdr.de/publications/Publ-23458
Publ.-Id: 23458