Human endothelial cell models in biomaterial research
Human endothelial cell models in biomaterial research
Hauser, S.; Jung, F.; Pietzsch, J.
Endothelial cell (EC) models have evolved as important tools in biomaterial research due to ubiquitously occurring interactions between implanted materials and the endothelium. However, screening the available literature has revealed a gap between material scientists and physiologists in terms of their understanding of these biomaterial–endothelium interactions and their relative importance. Consequently, EC models are often applied in nonphysiological experimental setups, or too extensive conclusions are drawn from their results. The question arises whether this might be one reason why, among the many potential biomaterials, only a few have found their way into the clinic. In this review, we provide an overview of established EC models and possible selection criteria to enable researchers to determine the most reliable and relevant EC model to use.
Keywords: endothelial cell heterogeneity; vascular grafts; stents; bone regeneration; soft tissue regeneration
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Trends in Biotechnology 35(2017)3, 265-277
DOI: 10.1016/j.tibtech.2016.09.007
Cited 97 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-24207
Publ.-Id: 24207