Kinetic Modeling


Kinetic Modeling

van den Hoff, J.

A mathematical description of the time-dependent tissue uptake and tissue clearance after injection of contrast agents or radioactively labeled tracers with suitable models (kinetic modeling) allows a detailed analysis of transport processes and metabolism in vivo. Such an analysis can provide at once quantitative information for several interesting parame- ters such as local blood volume, blood flow, distribution volumes, metabolic rates, binding potentials, and so forth. While the mathematical techniques are – with some reservations – in principle suited for data analysis in other tomographic modalities as well (notably CT and MRI), the broadest field of application is found in PET. We will focus especially on small animal PET in the following.

Keywords: PET; Kinetic Modeling; Small Animal Imaging

  • Book chapter
    Fabian Kiessling, Bernd J. Pichler, Peter Hauff: Small Animal Imaging: Basics and Practical Guide, Heidelberg: Springer International Publishing, 2017, 978-3-319-42200-8, 559-580
    DOI: 10.1007/978-3-319-42202-2_21

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Publ.-Id: 25808