Therapeutic options to overcome tumor hypoxia in radiation oncology


Therapeutic options to overcome tumor hypoxia in radiation oncology

Troost, E.; Koi, L.; Yaromina, A.; Krause, M.

Purpose
Expert review summarizing the overcome tumor cell hypoxia by treatment modification in radiation oncology.
Methods
An extensive literature search regarding various means of treatment modification was performed and key papers on those modifications were included in this review article.
Results
Based on the identified key papers the means to overcome hypoxia in radiation oncology were summarized in this review article, e.g., increasing levels of oxygen, combining radiotherapy with agents counteracting hypoxia, or modifying radiation treatment itself.
Conclusions
This review summarizes the results of preclinical and clinical studies counteracting hypoxia and highlights the measures that have found their way into clinical practice.

Keywords: Hypoxia; radiotherapy; oxygenation modification; systemic agents; radiation dose-escalation

Permalink: https://www.hzdr.de/publications/Publ-26034
Publ.-Id: 26034