Individual Response to Ionizing Radiation and Personalized Radiotherapy


Individual Response to Ionizing Radiation and Personalized Radiotherapy

Domina, E.; Philchenkov, A.; Dubrovska, A.

Radiation therapy remains one of the most effective cancer treatments. Nevertheless, biology driven personalized radiation therapy which enables to treat the patients according to the biological characteristics of the individual tumors and normal tissues still needs to be implemented into clinic. Understanding the mechanisms of radiation response in both tumors and normal tissues is necessary to develop reliable predictive biomarkers for tumor radioresistance and normal tissue toxicity as well as to exploit new therapeutic opportunities for tumor radiosensitization. In this paper, we review the mechanisms of tumor radiosensitivity, the early and late responses of normal tissues to therapeutic radiation exposure and discuss possible implementation of these mechanisms for biology-driven personalized radiation treatment.

Keywords: ionizing radiation; DNA damage; DNA repair; cell cycle checkpoints; radiosensitivity; cancer; cancer stem cells; radiotherapy; radioresistance; marker

Permalink: https://www.hzdr.de/publications/Publ-27522
Publ.-Id: 27522