Destabilization of DNA through interstrand crosslinking by UO22+
Destabilization of DNA through interstrand crosslinking by UO22+
Rossberg, A.; Abe, T.; Okuwaki, K.; Barkleit, A.; Fukuzawa, K.; Nakano, T.; Mochizuki, Y.; Tsushima, S.
UO22+ forms an interstrand crosslink between two different strands from a single DNA, which hardly affects the hydrogen bonds between nucleobase pairs whereas it destabilizes the π–π stacking between the two nucleobases in the vicinity of UO22+– bound phosphate. Thereby, fragility of DNA backbone increases upon UO22+ binding.
Keywords: Fragment molecular orbital method; DNA; chemotoxicity; uranyl(VI); interstrand crosslink; EXAFS
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