Tetranuclear Cu(II)-chiral complexes: Synthesis, characterization and biological activity


Tetranuclear Cu(II)-chiral complexes: Synthesis, characterization and biological activity

Peewasan, K.; Merkel, M. P.; Zarschler, K.; Stephan, H.; Anson, C. E.; Powell, A. K.

Tetranuclear chiral Cu(II)-Schiff-base complexes S-1 and R-1, were synthesised using enantiomerically pure (S)-H2L and (R)-H2L ligand respectively in the ratio of 1:1 of Cu(NO3)2 to (S/R)-H2L in MeOH at room temperature. A pair of polynuclear chiral Cu(II)-cluster complexes were characterized using single-crystal X-ray diffraction, elemental analysis, infrared and CD spectroscopy. The results revealed the importance of these chiral ligands encouraging the arrangement of copper metal in non-centrosymmetric polar packing. The potential of the novel Cu(II)-H2L complexes as biologically active compounds was assessed in particular regarding their anti-proliferative and anti-microbial properties.

Keywords: Metal-based drugs; Polynuclear Cu(II)-cluster; Enantiomerically pure Schiff-base ligand; Cell viability; Single-crystal X-ray diffraction

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Publ.-Id: 29357