Multifunctional Stealth Nanoparticles for Biomedical Applications


Multifunctional Stealth Nanoparticles for Biomedical Applications

Stephan, H.

Due to their size and surface charge, nanoparticles are often recognised as foreign objects by the body's own immune system and eliminated by its scavenger cells. A special role is played by the opsonisation of the particles, i.e. the surface is coated with special proteins (protein corona) in order to be more easily recognised and absorbed by phagocytic cells. Basically, there are two strategies to avoid phagocytosis. Firstly, the formation of a protein corona on nanoparticles is dramatically reduced by ultrasmall particles (< 5 nm) [1-2] and secondly, there is the possibility of producing so-called "stealth" particles that are invisible to the immune system. Here, the application of a zwitterionic protective coating (see Figure) is frequently used, which minimizes or prevents the surface binding of proteins [3-7].
This lecture will focus on the development and characterization of tiny nanoparticles, embracing silicon quantum dots, superparamagnetic iron oxide and upconverting nanophosphors for biomedical applications.
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[3] K. Pombo-García, K. Zarschler, L. Barbaro, J. A. Barreto, W. O’ Malley, L. Spiccia, H. Stephan, B. Graham, Small 10 (2014) 2516-2529.
[4] K. Pombo-García, S. Weiss, K. Zarschler, C.-S. Ang, R. Hübner, J. Pufe, S. Meister, J. Seidel, J. Pietzsch, L. Spiccia, H. Stephan, B.Graham, ChemNanoMat 2 (2016) 959-971.
[5] K. Pombo-García, C. L. Rühl, R. Lam, J. A. Barreto, C.-S. Ang, P. J. Scammels, P. Comba, L. Spiccia, B. Graham, T. Joshi, H. Stephan, ChemPlusChem 82 (2017) 638-646.
[6] A. Nsubuga, M. Sgarzi, K. Zarschler, M. Kubeil, R. Hübner, R. Steudtner, B. Graham, T. Joshi, H. Stephan, Dalton Trans. 47 (2018) 8595-8604.
[7] A. Nsubuga, K. Zarschler, M. Sgarzi, B. Graham, H. Stephan, T. Joshi, Angew. Chem. Int. Ed. 57 (2018) 16036-16040.

  • Invited lecture (Conferences)
    3nd International Conference on Translational Chemistry, 02.-05.12.2019, Lissabon-Caparica, Portugal

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Publ.-Id: 30175