Automated Synthesis of 16alpha-[18F]fluoroestradiol-3,17beta-disulphamate


Automated Synthesis of 16alpha-[18F]fluoroestradiol-3,17beta-disulphamate

Römer, J.; Füchtner, F.; Steinbach, J.; Kasch, H.

After 16alpha-[18F]fluoroestradiol ([18F]FES) has been successfully prepared in an automated module, the synthesis of 16alpha-[18F]fluoroestradiol-3,17beta-disulphamate ([18F]FESDS) is described as a module-assisted one-pot procedure which can provide 10 GBq [18F]FESDS with a radiochemical purity better than 99 %. The procedure is reliable and reproducible and requires a time of about 90 min. Because of its high sulphatase-inhibitory effect [18F]FESDS is thought to be a new PET tracer to image sites of high sulphatase activity.

Keywords: Fluorine-18; Nucleophilic fluorination; Sulphamoylation; Steroidal sulphatase inhibitors; Automated synthesis; PET tracer

  • Applied Radiation and Isotopes 55 (2001) 631-639.

Permalink: https://www.hzdr.de/publications/Publ-3349
Publ.-Id: 3349