The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation


The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation

de Roeck, L.; van der Weide, H.; Eekers, D.; Kramer, M.; Alapetite, C.; Bromstrand, M.; Burnet, N.; Calugaru, V.; Coremans, I.; Di Perri, D.; Harrabi, S.; Innalfi, A.; Klaver, Y.; Langendijk, J.; Méndez Romero, A.; Paulsen, F.; Roelofs, E.; de Ruysscher, D.; Timmermann, B.; Vitek, P.; Weber, D.; Whitfield, G.; Witt Nyström, P.; Zindler, J.; Troost, E. G. C.; Lambrecht, M.

Purpose: Treatment-related toxicity after irradiation of brain tumours has been underreported in the lit-
erature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim
of this European Particle Network (EPTN) collaborative project is to develop recommendations for uni-
form follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy.
Methods: A Delphi method-based consensus was reached among 24 international radiation-oncology
experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time
points.
Results: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using
multiple levels of recommendation. Level I includes all recommendations that are considered minimum
of care, whereas level II and III are optional evaluations in the advanced clinical or research setting,
respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed.
Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists
are defined.

Keywords: European Particle Therapy Network; Particle therapy; Follow-up; Toxicity; Brain tumour; Skull base tumour; Central nervous system

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Permalink: https://www.hzdr.de/publications/Publ-34532
Publ.-Id: 34532