Actions for increased yields and easier maintenance at the Tracerlab FXC-pro system in the synthesis of L-[11C]methionine


Actions for increased yields and easier maintenance at the Tracerlab FXC-pro system in the synthesis of L-[11C]methionine

Mäding, P.; Zessin, J.; Kreller, M.; Kopka, K.; Knieß, T.

L-[11C]Methionine ([11C]Met) is frequently used for the diagnosis of tumours located in brain, head and neck or for tumours induced by the multiple myeloma. The radio synthesis of [11C]Met commonly starts with [11C]CO2 with subsequent transformation to [11C]CH4 followed by transfer into [11C]CH3I which is used for final labelling of the precursor L-homocystein thiolactone hydrochloride (HCTL). [1,2] By performing these steps with the TRACERLab FXC-pro System (GE HC), however, we observed inconstant radiochemical yields and high maintenance efforts especially of the absorber material used within the gas phase iodination. Accordingly, we have searched for optimization of this radio synthesis procedure.

  • Poster
    20th European Symposium on Radiopharmacy and Radiopharmaceuticals, 24.-27.11.2022, Verona, Italien
  • Open Access Logo Contribution to proceedings
    Abstracts from the 20th European symposium on radiopharmacy and radiopharmaceuticals, 24.-27.11.2022, Verona, Italien
    EJNMMI Radiopharmacy and Chemistry
    DOI: 10.1186/s41181-023-00193-4

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Publ.-Id: 34888