5HT1A- and 5HT2A-receptors during social isolation in mice


5HT1A- and 5HT2A-receptors during social isolation in mice

Schiller, L.; Kretzschmar, M.; Oehler, J.; Brust, P.

Social isolation is an animal model for analysing behavioural and neurobiological processes caused by impairment of organism environment relationships. In previous studies we found time dependent changes in behaviour and central transmitter metabolism especially in the serotonergic and dopaminergic systems (Rilke et al. 1998a, Rilke et al. 1998b).
The aim of the study was to find out time-dependent effects of social isolation after 4 and 12 weeks at serotonin receptor 5HT1A- and 5HT2A-subtypes. Autoradiographic studies in distinct brain regions were carried out and the specific binding [fmol/mg protein] was determined. After 4 weeks specific binding for both receptor subtypes was diminished in all analysed brain regions of isolated mice in comparison to group housed animals. After 12 weeks of isolation, weaker alterations were found. Only the specific [3H]8-OH-DPAT binding for the 5HT1A-receptor in the hippocampus was significantly decreased. Furthermore up-regulations for both receptors were found in some regions. The results are discussed in relation to biochemical and behavioural changes.

  • Poster
    28th Göttingen Neurobiology Conference, Göttingen, 07.-10.06.2001
  • Contribution to proceedings
    Procceedings of the 4th Meeting of the German Neuroscience Society 2001, Volume II 28th Göttingen Neurobiology Conference (edited by Norbert Elsner and Georg W. Kreutzberg)

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Publ.-Id: 4428