Simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma: A potential pitfall in positron emission tomography imaging


Simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma: A potential pitfall in positron emission tomography imaging

Naumann, R.; Beuthien-Baumann, B.; Fischer, R.; Kittner, T.; Bredow, J.; Kropp, J.; Ockert, D.; Ehninger, G.

Positron emission tomography (PET) with [18F]fluorodeoxyglucose [18F]FDG has evolved as a method if increasingly clinical importance in the management of patients with malignant lymphoma. However, inflammatory lesions also accumulate [18F]FDG and may cause difficulties with interpretation. This report deals with 2 patients with simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma, a rare but known coincidence of diseases. In the first case, Hodgkin's disease could not be differentiated from eosinophilic granuloma. Positron emission tomography showed increased [18F]FDG uptake both in lymphoma manifestations and in the granuloma. In the second case with proven Hodgkin's disease, post-treatment examination showed a positive PET lesion in the mediastinal residual mass, which was interpreted as viable lymphoma. However, histologic examination revealed that it was an eosinophilic granuloma.

Keywords: Hodgkin's disease; 2-[18F]fluorodeoxyglucose; Eosinophilic granuloma; Langerhans cell histiocytosis; Chemotherapy; Mediastinoscopy; Radiation therapy

  • Clinical Lymphoma Vol. 3, No. 2 (2002) 121-124

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Publ.-Id: 5089