Darstellung und Charakterisierung von Nanopartikeln auf der Basis von [Ti2W10PO40]7- und Chitosan


Darstellung und Charakterisierung von Nanopartikeln auf der Basis von [Ti2W10PO40]7- und Chitosan

Stephan, H.; Meißner, T.; Bergmann, R.; Rode, K.; Kraus, W.; Emmerling, F.

Polynuclear metal compounds may have considerable potential as metallic drugs. Certain polyoxomatelates have been recognized to efficiently penetrate into tumour cells and to act as anti-tumour agents. Among a great variability of different metal-oxygen clusters formed, the Keggin type [XW12O40]x-, seems to be one of the most important compounds for medical applications. The structural characterization of two Keggin cluster anions will be reported (cf. Fig. 1). The lacunary sites of these polyanions are surrounded and stabilized by potassium cations and/or water molecules that form a hydrogen bond network with terminal and point-bridged oxygens of the cluster anion leading to a highly symmetric structure in the solid state.
The hydrolytic stability of the cluster anion [TiW11CoO40]8- is rather poor under physiologically relevant conditions. The degradation of the cluster structure has been observed at a pH of 7.4. In contrast to this, [Ti2W10PO40]7- is very stable under these conditions. This cluster anion rapidly forms associates with the biopolymer chitosan in the nanometer size range. These particles show a high hydrolytic stability. Interestingly, the cell uptake of [Ti2W10PO40]7- in tumor cell lines FaDu (human squamous carcinoma) and HT-29 (human adenocarcinoma) is remarkably enhanced in the presence of chitosan. Deposited in targeted cells, such heavy metal clusters have promising properties to be used in Photon Activation Therapy (PAT).

  • Poster
    BioNanoMaT "Bioinspired Nanomaterials for Medicine and Technologies", 23.-24.11.2005, Marl, Deutschland
  • Contribution to proceedings
    BioNanoMaT "Bioinspired Nanomaterials for Medicine and Technologies, 23.-24.11.2005, Marl, Deutschland
    Book of Abstracts, 67

Permalink: https://www.hzdr.de/publications/Publ-7751
Publ.-Id: 7751