Synthesis of a new type of 99mTechnetium labeled fatty acids for myocardial metabolism imaging and their Rhenium analogues
Synthesis of a new type of 99mTechnetium labeled fatty acids for myocardial metabolism imaging and their Rhenium analogues
Walther, M.; Bergmann, R.; Pietzsch, J.; Rode, K.; Mirtschink, P.; Stehr, S.; Heintz, A.; Wunderlich, G.; Kraus, W.; Pietzsch, H.-J.; Deussen, A.; Spies, H.
Technetium-labelled fatty acids intended for myocardial metabolism imaging and the respective rhenium model complexes were synthesized according to the 4+1 mixed-ligand approach and investigated in vitro and in vivo. In 4+1 mixed-ligand Tc(III) and Re(III) complexes the metal is coordinated by both a tripodal tetradentate thiolato ligand and by a monodentate isocyano ligand bearing the biomolecule. High heart extraction in perfused heart studies (up to 26% ID) and noticeable heart uptake of the 99mTc tracer in vivo being in the order of 2% ID/g at 5 min p.i., accompanied by a good heart to blood ratio of 8, confirms that the new Tc-compounds are mimics of fatty acids.
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Poster
7th International Symposium on Technetium in Chemistry and Nuclear Medicine, 06.-09.09.2006, Bressanone, Italy -
Contribution to external collection
U. Mazzi: Technetium, Rhenium and other Metals in Chemistry and Nuclear Medicine, Padova: SGEditoriali, 2006, 88-89884-04-5, 113-114
Permalink: https://www.hzdr.de/publications/Publ-8817
Publ.-Id: 8817