Tetrahydroquinoline and tetrahydroisoquinoline mixed ligand rhenium complexes with the SNS/S donor atom set
Tetrahydroquinoline and tetrahydroisoquinoline mixed ligand rhenium complexes with the SNS/S donor atom set
Zablotskaya, A.; Segal, I.; Lukevics, E.; Belyakov, S.; Spies, H.
New oxorhenium complexes with 3-methylazapentane-1,5-dithiolate (SNMeS) and thiol functionalized monodentate tetrahydroquinolyl and tetrahydroisoquinolyl derivatives have been synthesized by simultaneous reaction of [PPh3]2[Re(O)Cl3] with tridentate HSNMeSH and the corresponding N-heterocycle containing thiol. The characterization of complexes involved elemental analysis, IR, 1H and 13C NMR spectroscopy and X-ray crystallographic analysis. The nature of the heterocycle in monodentate ligand, even situated at the distance of two methylene group length, has been found to have a significant influence on the molecular conformation. Metal complexes were found to be active in psychotropic in vivo and cytotoxicity in vitro screening.
Keywords: rhenium; mixed-ligand oxorhenium complexes; tetrahydroquinoline; tetrahydroisoquinoline; molecular structure; psychotropic activity; cytotoxicity; metal-based drugs
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Applied Organometallic Chemistry 21(2007)4, 288-293
DOI: 10.1002/aoc.1201
Cited 8 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-10101