Carbohydration of 1,4,8,11-tetraazacyclotetradecane (cyclam): synthesis and binding properties toward concanavalin A
Carbohydration of 1,4,8,11-tetraazacyclotetradecane (cyclam): synthesis and binding properties toward concanavalin A
Stephan, H.; Röhrich, A.; Noll, S.; Steinbach, J.; Kirchner, R.; Seidel, J.
Two novel glycocluster ligands with cyclam core bearing thiourea-linked D-glucose and 2-acetamido-2-deoxy-D-glucose at the periphery have been synthesized. The interaction with concanavalin A has been studied by isothermal titration microcalorimetry for characterizing protein-ligand interactions. The sugar-containing multivalent ligands showed higher association affinity compared to the sugar monomers which is attributed to an entropy driven glycoside clustering effect.
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Tetrahedron Letters 48(2007), 8834-8838
DOI: 10.1016/j.tetlet.2007.10.071
Cited 10 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-10412