Facile synthesis of various nitro-substituted derivatives of semaxinib (SU 5416)
Facile synthesis of various nitro-substituted derivatives of semaxinib (SU 5416)
Knieß, T.; Kuchar, M.; Wüst, F.
The synthesis of novel nitro-substituted derivatives of the tyrosine kinase inhibitor SEMAXINIB (SU 5416) is described. The reaction of various substituted oxindoles with 3,5-dimethylpyrrol-2-carbaldehyde derivatives under Knoevenagel conditions gave an array of nitro-substituted derivatives of Semaxinib (SU 5416) in high yields of 72-87%.
Keywords: Nitration; semaxinib; tyrosine kinase
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Synthetic Communications 38(2008), 3017-3022
DOI: 10.1080/00397910802044256
ISSN: 0039-7911 print/1532
Cited 10 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-10779