Specific targeting of hypoxic tumor tissue with nitroimidazole-peptide conjugates

Nitroimidazole–peptide conjugates: Attachment of a nitroimidazole unit to a cell-penetrating peptide was used to create conjugates able to target hypoxic tumor tissue. In vivo studies have demonstrated the successful delivery of these conjugates to even less well-perfused hypoxic regions in solid tumors. This approach provides a targeted delivery system with the option to use it as an imaging agent or to conjugate it with therapeutics.