Development of potential tumour imaging agents by 4-[18F]

Development of potential tumour imaging agents by 4-[18F]

Mäding, P.; Scheunemann, M.; Steinbach, J.; Bergmann, R.; Iterbeke, K.; Tourwe, D.; Johannsen, B.

The 4-[18F]fluorobenzoyl compounds of Neurotensin(8-13) (NT(8-13)) as well as [Arg8pseudo(CH2NH)Arg9]NT(8-13) were obtained by reaction of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) with these peptides in aqueous buffered solutions at pH 8.3 in r.c.y. of up to 43 % (related to [18F]SFB; decay-corrected) within 80 min (including HPLC purification). This is the first example for the specific radiolabelling of the alpha-amino group at the N-terminal arginine unit of peptides using [18F]SFB.

Keywords: Neurotensin(8-13); 18F-labelling; [18F]SFB; neurotensin receptor; pseudopeptide

  • Lecture (Conference)
    8th Conference of Central European Division of International Isotope Society, Bad Soden, 10.-11.6.1999
  • Abstract in refereed journal
    J. Labelled Compd. Radiopharm. 42 (1999) 987-1022

Permalink: https://www.hzdr.de/publications/Publ-1764