Tc(V) and Re(V) complexes of N-(MAG1)-Histamine

The synthesis of N-(MAG1)-histamine and the preparation of its Tc and Re complexes are reported. As proven by spectroscopic methods, HPLC investigations and by X-ray structure analysis, N-(MAG1)-histamine forms stable, neutral and square pyramidal 1:1 coordination compounds with MO3*-cores of Tc and Re. The preparation of the isostructural 99mTcO(V)-N-(MAG1)-histamine complex has been achieved with 80-95% radiochemical yield.