Rhenium and technetium complexes with nucleic acid components

Re/Tc labelled nucleobases and nucleosides are developed and characterized in connection with cell uptake studies on cultured normal and tumour cells [1,2]. Stable Re and Tc complexes of nucleic acid components have been prepared where uracil derivatives are either involved in a mercaptoacetyl glycine (MAG) SN₃ coordination sphere or are part of "3+1" mixed-ligand complexes. Furthermore a prelabelling method has been successfully used for coupling the nucleic acid components to a performed Re/Tc complex.
Uptake of such complexes into proliferating cultured normal and tumour cells and their crude cytosolic and nuclear fractions, including postincubation effects and the influence of the metabolic state of the cells, has been observed.