Radiosynthesis and in vivo Evaluation of a 18F-Labelled Styryl-Benzoxazole Derivative for ß-Amyloid Targeting
Radiosynthesis and in vivo Evaluation of a 18F-Labelled Styryl-Benzoxazole Derivative for ß-Amyloid Targeting
Ribeiro Morais, G.; Kniess, T.; Bergmann, R.; Gano, L.; Abrunhosa, A.; Santos, I.; Paulo, A.
The formation of β-amyloid deposits is considered a histopathological feature of Alzheimer´s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD. Herein, we describe the radiosynthesis of the radiofluorinated styryl benzoxazole derivative [18F]-[2-[N-methyl-N-(2`-fluoroethyl)-4`-aminostyryl]benzoxazole] ([18F]-1) and its pre-clinical evaluation, including metabolic and biodistribution studies in male Wistar rats. The in vivo biological evaluation of [18F]-1 showed that this new radiotracer has a moderate brain uptake with a slow brain washout and a poor in vivo stability.
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Applied Radiation and Isotopes 82(2013), 100-104
DOI: 10.1016/j.apradiso.2013.07.003
Permalink: https://www.hzdr.de/publications/Publ-19044