Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application
Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application
Patt, M.; Schildan, A.; Habermann, B.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wilke, S.; Smits, R.; Hoepping, A.; Wagenknecht, G.; Steinbach, J.; Brust, P.; Sabri, O.
A fully automatized radiosynthesis of (+)- and (−)-[18F]Flubatine ((+)- and (−)NCFHEB) by means of a commercially available synthesis module (TRACERlab FX FN) under GMP conditions is reported. Radiochemical yields of 30% within an overall synthesis time of 40 min were achieved in more than 70 individual syntheses. Specific activities were approximately 3000 GBq/μmol and radiochemical purity was determined to be at least 97%.
Keywords: Fluorine-18; NCFHEB; Flubatine; α4β2 Nicotinic acetylcholine receptors; GMP; Automation
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Applied Radiation and Isotopes 80(2013), 7-11
Online First (2013) DOI: 10.1016/j.apradiso.2013.05.009
ISSN: 0969-8043
Cited 19 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-19102
