Interactions of medicinal and biological relevant anions with functionalized dendrimers

Due to their unique topology and unusual guest-binding behaviour, dendrimers are promising reagents for use in diagnostic imaging and therapy. We are especially interested in efficient binding and transport of medicinal and biological relevant anions as pertechnetate and the nucleotides AMP, ADP and ATP. Poly(propylenamine)-Dendrimers (POPAM) of different generations have been functionalized at the periphery with the goal to obtain a hydrophobic shell. The dendrimers synthesized (cf. Fig.) were characterized by solvent extraction experiments at the system pertechnetate,(nucleotide)-buffer-H₂O/dendrimer-CHCl₃. A dendritic effect is clearly visible of all dendrimers investigated. The influence of pH and temperature on the extraction of pertechnetate and nucleotides with dendrimers is reported.