Estimating the influence of magnetization transfer effects on cerebral blood flow quantification in pseudo-continuous arterial spin labeling

Petr, Jan; Schramm, Georg; Hofheinz, Frank; Maus, Jens; Hoff, Jörg van den

Estimating the influence of magnetization transfer effects on cerebral blood flow quantification in pseudo-continuous arterial spin labeling

Petr, J.; Schramm, G.; Hofheinz, F.; Maus, J.; van den Hoff, J.

The magnetization transfer (MT) effects were studied in pseudo-continuous ASL (pCASL). The MT exchange rate was obtained from two pCASL sequences with and without labeling acquired at multiple delays. A mean white-matter MT exchange rate was obtained and the exchange rate in blood was derived from it. Effect on CBF quantification was then calculated using the standard pCASL quantification model for different distances from the labeling plane and different blood velocities in the arteries. CBF underestimation of up to 6% was shown in the slices closest to the labeling plane if the MT effects were ignored

Involved research facilities

PET-Center

Contribution to proceedings
Annual Meeting of the International Society for Magnetic Resonance in Medicine, ISMRM 2014, 10.-16.05.2014, Milano, Italy
Proceedings of the International Society for Magnetic Resonance in Medicine, 2677
Lecture (Conference)
Annual Meeting of the International Society for Magnetic Resonance in Medicine, ISMRM 2014, 10.-16.05.2014, Milano, Italy

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