Use of Target Capsules for Radiolabeling of Platinum Nanoparticles with a Modified Nirta® Solid Target Station (Cyclone 18/9)

The increased use of nanoparticles (NP) in technical processes and consumer products requires a comprehensive and thorough nanosafety research. Challenging is the sensitive and selective detection of NP in different environments. Here radiolabeling offers a unique tool for even in situ detection of NP for nanosafety studies. Often radiotracers are introduced into NP via the NP synthesis process. Highest activity concentrations are achievable. However, this strategy requires careful characterization of the synthesized NP to allow a comparison with the commercially available NP. Mostly there is very little detailed knowledge about the commercial synthesis process. The direct activation of NP can overcome this limitation. In this study we present the use of a Cyclone 18/9 for the activation of 10 nm Pt-NP. The activation yields into the NP labeling with Au radionuclides.