Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation
Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation
Rothe, R.; Schulze, S.; Neuber, C.; Hauser, S.; Rammelt, S.; Pietzsch, J.
In this third in a series of reviews on adjuvant drug-assisted bone healing, further approaches aiming at influencing the healing process are discussed. Local and systemic modulation of bone metabolism is persued with use of a number of drugs with completely different indications, which are characterized by a pleiotropic spectrum of action. These include drugs used to treat lipid disorders (HMG-CoA reductase inhibitors), hypertension (ACE inhibitors), osteoporosis (bisphosphonates), cancer (proteasome inhibitors) and others. Potential applications to enhance bone healing are discussed.
Keywords: bisphosphonates; bone metabolism; critical-size bone defects; small molecules; statins; strontium; Wnt signaling
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Clinical Hemorheology and Microcirculation 73(2019), 439-488
DOI: 10.3233/CH-199104
ISSN: 1386-0291
Cited 8 times in Scopus
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Permalink: https://www.hzdr.de/publications/Publ-29218