Using ASL perfusion images for spatial normalization in a pediatric population with craniosynostosis

Spatial normalization is an important step for image processing and quantification of regional brain perfusion values using arterial spin labeling (ASL) MRI and is typically performed via high-resolution structural scans. Structural segmentation and/or registration is complicated when gray-white matter T1w contrast is low and changing in early phases of myelination in newborns. Craniosynostosis is a condition where the decision for surgical treatment in the first years of life is supported by brain imaging. In this study, we investigate if ASL CBF image contrast can be directly used for spatial normalization, in both healthy controls and a non-syndromic type of craniosynostosis.