S-[18F]fluoromethyl-(+)-McN5652 - A potential PET tracer for imaging the serotonin transporter

S-[18F]fluoromethyl-(+)-McN5652 - A potential PET tracer for imaging the serotonin transporter

Zessin, J.; Eskola, O.; Brust, P.; Berman, J.; Marjamäki, P.; Kretzschmar, M.; Grönroos, T.; Wittrisch, H.; Haaparanta, M.; Lehikoinen, P.; Solin, O.; Steinbach, J.; Johannsen, B.

The S-[18F]fluoromethyl analogue of (+)-McN5652 was prepared by reaction of demethylated (+)-McN5652 with [18F]bromofluoromethane in decay-corrected radiochemical yields of about 18% (related to [18F]fluoride). Autoradiographic ex vivo studies with rats and PET studies with piglets indicate that the 18F-labelled analogue of (+)-McN5652 is a potential PET tracer for the imaging of the serotonin transporter.

Keywords: McN5652; [18F]bromofluoromethane; PET; serotonin transporter

  • Lecture (Conference)
    14th International Symposium on Radiopharmaceutical Chemistry, 10 - 15.6.2001, Interlaken, Schweiz

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