Cardiovascular and cerebrovascular health in 70-year-olds: a population-based ASL study
Cardiovascular and cerebrovascular health in 70-year-olds: a population-based ASL study
Dijsselhof, M. B. J.; James, S.-N.; Lorenzini, L.; Collij, L.; Thomas, D. L.; Scott, C.; Manning, E.; Józsa, T. I.; Cash, D.; Study, I.; Sudre, C.; Hughes, A. D.; Richards, M.; Barkhof, F.; Schott, J.; Petr, J.; Mutsaerts, H. J. M. M.
While mid-life cardiovascular pathology may lead to late-life cognitive decline, our understanding of the role of cerebrovascular health as an intermediate biomarker is limited. We explored the association between cardiovascular health biomarkers and cross-sectional and longitudinal cerebrovascular health assessed by ASL MRI in Insight46, a well-characterised cognitively normal population-based sample.
We found several cross-sectional and longitudinal associations between blood pressure and CBF. These findings suggest that the effects of BP on cerebrovascular health can be imaged with ASL perfusion MRI, possibly offering opportunities to prevent or intervene before cognitive decline sets in.
Involved research facilities
- PET-Center
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Contribution to proceedings
2023 ISMRM & ISMRT Annual Meeting & Exhibition, 03.06.2023, Toronto, Canada
ISMRM '23: Proceedings of the ISMRM 31th Annual Meeting & Exhibition, 1304 -
Lecture (Conference)
2023 ISMRM & ISMRT Annual Meeting & Exhibition, 03.06.2023, Toronto, Canada -
Contribution to proceedings
OHBM '23: Proceedings of the Organization for Human Brain Mapping Annual Meeting, 22.07.2023, Montreal, Canada -
Poster
OHBM '23: Proceedings of the Organization for Human Brain Mapping Annual Meeting, 22.07.2023, Montreal, Canada
Permalink: https://www.hzdr.de/publications/Publ-38142
