DEveloping Blood-Brain barrier arterial spin labeling as a non-Invasive Early biomarker (DEBBIE)

Padrela, Beatriz; Tee, Mervin; Sneve, Markus; Mahroo, Amnah; Geier, Oliver; Thomas, David; Morgan, Catherine; Moyaert, Paulien; Ozturk, Esin; Nordhøy, Wibeke; Pålhaugen, Lene; Linn, Jennifer; Selnes, Per; Eickel, Klaus; Konstandin, Simon; Kuijer, Joost; Hoinkiss, Daniel; Breutigam, Nora; Buck, Mareike; Achten, Rik; Barkhof, Frederik; Hilal, Saima; Fladby, Tormod; Anazodo, Udunna; Petr, Jan; Mutsaerts, Henk J. M. M.; Günther, Matthias

DEveloping Blood-Brain barrier arterial spin labeling as a non-Invasive Early biomarker (DEBBIE)

Padrela, B.; Tee, M.; Sneve, M.; Mahroo, A.; Geier, O.; Thomas, D.; Morgan, C.; Moyaert, P.; Ozturk, E.; Nordhøy, W.; Pålhaugen, L.; Linn, J.; Selnes, P.; Eickel, K.; Konstandin, S.; Kuijer, J.; Hoinkiss, D.; Breutigam, N.; Buck, M.; Achten, R.; Barkhof, F.; Hilal, S.; Fladby, T.; Anazodo, U.; Petr, J.; Mutsaerts, H. J. M. M.; Günther, M.

One of the earliest signs of Alzheimer’s disease (AD) is the loss of blood-brain barrier (BBB) integrity. Arterial spin labeling (ASL) MRI is a non-invasive way to measure perfusion and several other hemodynamic and physiological parameters, including vascular permeability. The DEveloping BBB-ASL as non-Invasive Early biomarker (DEBBIE) consortium aims to develop and integrate innovative techniques to allow robust BBB permeability assessments by ASL to develop a sensitive, non-invasive, and early biomarker for AD and related dementias. This work summarizes our planned efforts to develop and establish an MRI-based BBB permeability biomarker.

Involved research facilities

PET-Center

Contribution to proceedings
2023 ISMRM & ISMRT Annual Meeting & Exhibition, 03.06.2023, Toronto, Canada
ISMRM '23: Proceedings of the ISMRM 31th Annual Meeting & Exhibition, 0367
Lecture (Conference)
2023 ISMRM & ISMRT Annual Meeting & Exhibition, 03.06.2023, Toronto, Canada

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