Perfusion and Time of Exchange Measurements Using BBB-ASL in Gliomas: The Initial Experience

Turhan, Gülce; Çetin, Ayşe İrem; Mahroo, Amnah; Padrela, Beatriz; Konstandin, Simon; Hoinkiss, Daniel Christopher; Breutigam, Nora Josefin; Eickel, Klaus; Petr, Jan; Mutsaerts, Henk; Danyeli, Ayca Ersen; Ozduman, Koray; Guenther, Matthias; Dincer, Alp; Ozturk-Isik, Esin

Perfusion and Time of Exchange Measurements Using BBB-ASL in Gliomas: The Initial Experience

Turhan, G.; Çetin, A. İ.; Mahroo, A.; Padrela, B.; Konstandin, S.; Hoinkiss, D. C.; Breutigam, N. J.; Eickel, K.; Petr, J.; Mutsaerts, H.; Danyeli, A. E.; Ozduman, K.; Guenther, M.; Dincer, A.; Ozturk-Isik, E.

Subtle changes in BBB integrity might be missed by contrast-enhanced T1-weighted MRI. Blood-brain barrier arterial spin labeling (BBB-ASL) is a new technique to assess BBB disruptions. In this work, we measured the cerebral blood flow (CBF) and exchange time (Tex) values of the tumor, normal-appearing white matter, and normal-appearing gray matter regions in gliomas using BBB-ASL technique. Our results indicated higher CBF and leakier BBB in contrast-enhanced regions of gliomas than in the normal-appearing GM.

Involved research facilities

PET-Center

Contribution to proceedings
2023 ISMRM & ISMRT Annual Meeting & Exhibition, 03.06.2023, Toronto, Canada
ISMRM '23: Proceedings of the ISMRM 31th Annual Meeting & Exhibition, 1757
Poster
2023 ISMRM & ISMRT Annual Meeting & Exhibition, 03.06.2023, Toronto, Canada

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