Associations between ASL-derived cerebrovascular health and cognitive performance: results from the Insight 46 study

Associations between ASL-derived cerebrovascular health and cognitive performance: results from the Insight 46 study

Dijsselhof, M. B.; Lu, K.; Lorenzini, L.; Collij, L. E.; James, S.-N.; Thomas, D. L.; Scott, C. J.; Manning, E. N.; Cash, D. M.; Hughes, A. D.; Richard, M.; Barkhof, F.; Schott, J. M.; Petr, J.; Mutsaerts, H. J. M. M.

Cardiovascular and cerebrovascular pathology may accelerate brain aging and cognitive
decline. Structural cerebrovascular imaging biomarkers, such as white matter
hyperintensities, reflect mostly irreversible accumulated damage. In contrast, cerebral blood
flow (CBF), measured with arterial spin labelling (ASL) perfusion MRI, is a potential early
haemodynamic biomarker of cognitive impairment. However, our understanding of
physiological CBF variability and its relation with cognition is limited.

Involved research facilities

  • PET-Center
  • Poster
    Alzheimer's Association International Conference, 15.07.2023, Amsterdam, The Netherlands
  • Open Access Logo Contribution to proceedings
    Alzheimer's Association International Conference, 15.07.2023, Amsterdam, Alzheimer's & Dementia
    Alzheimer's & Dementia
    DOI: 10.1002/alz.081945

Permalink: https://www.hzdr.de/publications/Publ-38202