Blood-brain barrier permeability measured with arterial spin labeling as potential cerebrovascular biomarker over the lifespan
Blood-brain barrier permeability measured with arterial spin labeling as potential cerebrovascular biomarker over the lifespan
Padrela, B. E.; Tee, M.; Markus, S. H.; Geier, O.; Mahroo, A.; Grydeland, H.; Fladby, T.; Eickel, K.; Günther, M.; Barkhof, F.; Hilal, S.; Mutsaerts, H.-J.; Petr, J.
Blood-brain barrier (BBB) dysfunction is considered a hallmark of Alzheimer’s disease
(AD), making non-invasive imaging of BBB with arterial spin labeling (ASL) MRI a potential imaging
biomarker (BBB-ASL). However, the normal BBB development over the lifespan is unknown. Here, we
created population-based BBB-ASL permeability reference maps, and aimed to investigate associations
between BBB-ASL, chronological age, and biological cerebrovascular age – expressed as white matter
hyperintensities (WMH) volume
Involved research facilities
- PET-Center
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Contribution to proceedings
Alzheimer's Association International Conference, 15.07.2023, Amsterdam, The Netherlands -
Poster
Alzheimer's Association International Conference, 15.07.2023, Amsterdam, The Netherlands -
Contribution to proceedings
OHBM '23: Proceedings of the Organization for Human Brain Mapping Annual Meeting, 22.07.2023, Montreal, Canada -
Poster
OHBM '23: Proceedings of the Organization for Human Brain Mapping Annual Meeting, 22.07.2023, Montreal, Canada
Permalink: https://www.hzdr.de/publications/Publ-38206
