Simultaneous preparation of 16alpha-[18F]fluoroestradiol-sulphamates in an automated module. A high-yield procedure for 16alpha-[18F]fluoroestradiol-17beta-sulphamate

Simultaneous preparation of 16alpha-[18F]fluoroestradiol-sulphamates in an automated module. A high-yield procedure for 16alpha-[18F]fluoroestradiol-17beta-sulphamate

Römer, J.; Füchtner, F.; Steinbach, J.; Kasch, H.

After successful synthesizing 16alpha-[18F]fluoroestradiol-3,17beta-disulphamate in an automatic procedure, we studied the conditions for obtaining 16alpha- [18F]fluoroestradiol-mono-sulphamates in a similar manner. The described procedure can simultaneously provide approximately 3 GBq of 16alpha-[18F]fluoroestradiol-3-sulphamate and 1 GBq of 16alpha-[18F]fluoroestradiol-17beta-sulphamate of high radiochemical purity. By treating 16alpha-[18F]fluoroestradiol-3,17beta-disulphamate with Kryptofix 2.2.2 and potassium carbonate, 16alpha-[18F]fluoroestradiol-17beta-sulphamate also becomes available at high radioactivity.

Keywords: fluorine-18; nucleophilic fluorination; sulphamoylation; automated synthesis; PET tracer

  • Poster
    14th International Symposium on Radiopharmaceutical Chemistry, Interlaken/Schweiz, 10.-15.06.2001
  • Journal of Labelled Compounds and Radiopharmaceuticals 44 (2001) 689-700

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