Synthesis and properties of triethyl(triphenyl)siloxyalkyl(aryl)thiolato(3-thiapentane-1,5-dithialato)oxorhenium(V)- potential brain seeking agents

Four triethyl(triphenyl)siloxyalkyl(aryl)thiolato(3-thiapentane-1,5-dithialato)oxorhenium(V) complexes viz. triethylsiloxyethylthiolato-(3-thiapentane-1,5-dithialato)oxorhenium(5), triethylsiloxypropylthiolato-(3-thiapentane-1,5-dithialato)oxorhenium(6), triethylsiloxyphenylthiolato-(3-thiapentane-1,5-dithialato)oxorhenium(8) and triphenylsiloxyethylthiolato-(3-thiapentane-1,5-dithialato)oxorhenium(7) were synthesized by a new route reacting chloro-(3-thiapentane-1,5-dithialato)oxorhenium(V) with bis silylated mercaptoalkanols or mercaptophenol. Stability of the compounds in acetonitrile-water (1:1) solution at different temperature and pH was studied by reverse phase HPLC method. Compound 5 was found to be the most stable in acetonitrile-water system with respect to both temperature and pH changes.