Synthesis of hydroxyl silylated rhenium and (^99mTc)technetium ‚3+1'mixed ligand complexes

The synthesis of hydroxyl silylated thiols as monodentate ligands is described. These monodentates were used to build with Re and ^99mTc trimethyl-, triethyl- and triphenyl-silylated ‚3+1' mixed ligand complexes, using 3thiapentane-1,5-dithiol as co-ligand. The Re complexes were characterized by ¹H NMR and elemental analysis, the ^99mTc complexes were detected by radio HPLC. While the trimethyl silylated derivatives hydrolysed in aqueous media, the triethyl- and triphenyl silylated complexes have proved to be stable in neutral solutions.