Synthesis and copper(II) complexation of glycodendrimers having a cyclam-core

Derivatives of cyclam and its metal complexes are of considerable interest in bioinorganic chemistry, biology and medicine. In the latter nexus, cyclam compounds show anti-HIV activities, and metallated cyclams may be used in radiotherapy applying 64/67Cu or 186/188Re.1 Recently, we could show that the grafting of polyethylene glycol arms on the cyclam core leads to both a higher complex stability and an increasing shielding effect for copper(II).2 In this contribution the synthesis of two novel cyclams 1 and 2 (cf. Fig. 2) carrying sugar molecules as terminal groups will be presented. The complex formation of these glycodendrimers with copper(II) has been studied by UV-vis and time-resolved laser-induced fluorescence (TRLFS) measurements showing rapid formation of 1:1 complexes.