Module-assisted synthesis of the bifunctional labelling agent N-succinimidy 4-[18F]fluorobenzoate ([18F]SFB)

Module-assisted synthesis of the bifunctional labelling agent N-succinimidy 4-[18F]fluorobenzoate ([18F]SFB)

Mäding, P.; Füchtner, F.; Wüst, F.

The three-step radiosynthesis of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) was adapted to a remotely controlled synthesis module. After optimization of the reaction conditions, the final [18F]SFB was obtained in decay-corrected radiochemical yields of 34 - 38 % (related to [18]fluoride; n = 12) within a synthesis time of 68 min. The radiochemical purity was in the range of 93 -96 %.

Keywords: 18F-labelling; Positron emission tomography (PET); [18F]SFB; Automated module synthesis

  • Applied Radiation and Isotopes 63(2005), 329-332

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