Lack of efficacy of imatinib in a patient with metastatic Leydig cell tumor
Lack of efficacy of imatinib in a patient with metastatic Leydig cell tumor
Froehner, M.; Beuthien-Baumann, B.; Dittert, D.-D.; Schuler, U.; Wirth, M. P.
Imatinib is a tyrosine kinase inhibitor with activity in gastrointestinal stromal tumor and a variety of other solid and hematological malignancies. Studies in vitro and in a mouse model suggested that the imatinib might also be active in malignant Leydig cell tumor. We report on theto our knowledgefirst treatment experiment with imatinib in a patient with metastatic Leydig cell tumor. Unfortunately, the tumor progressed during treatment.
Keywords: Imatinib; Leydig cell tumor; Testicular cancer; Metastases; Positron emission tomography
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Cancer Chemotherapy and Pharmacology 58(2006)5, 716-718
DOI: 10.1007/s00280-005-0181-6
Cited 16 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-8176