Protein Oxidation and Disease 2006. In: Protein Oxidation and Disease, Recent Research Developments in Pathological Biochemistry 1

Since the pioneering studies on oxidative modification of proteins exposed to ionizing radiation by swallow, Garrison, Schuessler, and colleagues and on oxidative inactivation of enzymes by metal-catalyzed oxidation systems by Earl Stadtman's group and colleagues, recent progresses in life sciences have led to the development of a range of excellent methods and experimental approaches and procedures that enable an always more detailed investigation and evaluation of the phenomenon of Protein Oxidation at both the micro- and macrostructural level under physiological and pathophysiological conditions, respectively. In this line, this volume "Protein Oxidation and Disease" assesses critically recent evidence that underpins the argument that oxidative damage to proteins is a significant causative or associated factor in aging as well as the etiology, progression, and manifestation of various human diseases.