Publications of Institute of Radiopharmaceutical Cancer Research

1324 Publications

2024

Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol

Padrela, B.; Mahroo, A.; Tee, M.; Sneve, M. H.; Moyaert, P.; et al. (43 authors)

64Cu tumor labeling with hexadentate picolinic acid-based bispidine immunoconjugates

Kubeil, M.; Neuber, C.; Starke, M.; Arndt, C.; Rodrigues Loureiro, L. R.; et al. (11 authors)

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Toyohara, J.; Vugts, D.; Kiß, O.; Todde, S.; Li, X.-G.; et al. (24 authors)

Reproducibility of Arterial Spin Labeling Cerebral Blood Flow image processing: A Report of The ISMRM Open Science Initiative for Perfusion Imaging and the ASL MRI Challenge

Paschoal, A. M.; Woods, J. G.; Pinto, J.; Bron, E. E.; Petr, J.; et al. (26 authors)

Value of [18F] FDG PET/CT parameters of the primary tumor in assessing overall survival in NSCLC patients with cN1-cN3 lymph nodes involvement

Cegla, P.; Hofheinz, F.; Czepczyński, R.; Witkowska, K.; van den Hoff, J.; et al. (8 authors)

  • Open Access Logo Reports of Practical Oncology and Radiotherapy 29(2024)1, 97-102
    DOI: 10.5603/rpor.99360

RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma

Abdelfatah Saleh Hassan, H. A.; Mitwasi, N.; Rodrigues Loureiro, L. R.; Kegler, A.; Elizabeth González Soto, K.; et al. (11 authors)

The crystal structure of (2-diphenylphosphanylphenyl) 2-[7-(dimethylamino)-2-oxochromen-4-yl]acetate, C31H26NO4P

Mamat, C.; Köckerling, M.

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

Maisonial-Besset, A.; Kryza, D.; Kopka, K.; Levesque, S.; Moreau, E.; et al. (7 authors)

Impact of Viscosity on Human Hepatoma Spheroids in Soft Core-Shell Microcapsules

Peng, X.; Janićijević, Ž.; Lemm, S.; Hauser, S.; Knobel, M.; et al. (8 authors)

Bone marrow-derived mesenchymal stromal cells obstruct AML-targeting CD8+ clonal effector and CAR T cell function while promoting a senescence-associated phenotype

Towers, R.; Trombello, L.; Fusenig, M.; Tunger, A.; Baumann, A.-L.; et al. (16 authors)

Alpha-emitting Radionuclides: Current Status and Future Perspectives

Miederer, M.; Benešová-Schäfer, M.; Mamat, C.; Kästner, D.; Pretze, M.; et al. (11 authors)

Design and Development of Transient Sensing Devices for Healthcare Applications

Janićijević, Ž.; Huang, T.; Sandoval Bojorquez, D. I.; Tonmoy, T. H.; Pané, S.; et al. (7 authors)

[¹⁸F]Fluspidine – a PET tracer for imaging of σ1 receptors in the central nervous system

Ludwig, F.-A.; Laurini, E.; Schmidt, J.; Pricl, S.; Deuther-Conrad, W.; et al. (6 authors)

Production of medical radionuclides in the Center for Radiopharmaceutical Tumor Research – a status report

Kreller, M.; Walther, M.; Brühlmann, S. A.; Knieß, T.; Kopka, K.

Portable Droplet-Based Real-Time Monitoring of Pancreatic α-Amylase in Postoperative Patients

Zhao, X.; Kolbinger, F. R.; Distler, M.; Weitz, J.; Makarov, D.; et al. (7 authors)

Production of the PET radionuclide 61Cu via the 62Ni(p,2n)61Cu Nuclear Reaction

Brühlmann, S. A.; Walther, M.; Kopka, K.; Kreller, M.

Preclinical evaluation of an ¹⁸F-labeled Nε-acryloyllysine piperazide for covalent targeting of transglutaminase 2

Wodtke, R.; Laube, M.; Hauser, S.; Meister, S.; Ludwig, F.-A.; et al. (9 authors)

Chelator Impact: Investigating the Pharmacokinetic Behavior of Copper-64 Labeled PD-L1 Radioligands

Krutzek, F.; Donat, C.; Stadlbauer, S.

Position Paper to facilitate patient access to radiopharmaceuticals - considerations for a suitable pharmaceutical regulatory framework

Korde, A.; Patt, M.; Selivanova, S.; Scott, A.; Hesselmann, R.; et al. (15 authors)

The Past, Present, and Future of the Brain Imaging Data Structure (BIDS)

Poldrack, R. A.; Markiewicz, C. J.; Appelhoff, S.; Ashar, Y. K.; Auer, T.; et al. (112 authors)

Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results

Pasternak, M.; Mirza, S.; Luciw, N.; Mutsaerts, H.; Petr, J.; et al. (42 authors)

Improving susceptibility of neuroendocrine tumors to radionuclide therapies: personalized approaches towards complementary treatments

Richter, S.; Steenblock, C.; Lemm, S.; Ziegler, C. G.; Bechmann, N.; et al. (8 authors)

Effect of physical exercise on brain perfusion in chemotherapy-treated breast cancer patients: a randomized controlled trial (PAM study)

Koevoets, E. W.; Petr, J.; Monninkhof, E. M.; Geerlings, M. I.; Witlox, L.; et al. (15 authors)

  • Open Access Logo Journal of Magnetic Resonance Imaging 59(2024)5, 1667-1680
    Online First (2023) DOI: 10.1002/jmri.28967

Brain tumor imaging without gadolinium-based contrast agents: Feasible or Fantasy?

Wamelink, I. J. H. G.; Azizova, A.; Booth, T. C.; Mutsaerts, H. J. M. M.; Ogunleye, A.; et al. (9 authors)

ASL lexicon and reporting recommendations: A consensus report from the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI)

Suzuki, Y.; Clement, P.; Dai, W.; Dolui, S.; Fernández-Seara, M.; et al. (11 authors)

  • Open Access Logo Magnetic Resonance in Medicine 91(2024), 1743-1760
    Online First (2023) DOI: 10.1002/mrm.29815

Shell engineering in soft alginate-based capsules for culturing liver spheroids

Peng, X.; Janićijević, Ž.; Lemm, S.; Laube, M.; Pietzsch, J.; et al. (7 authors)

The Open Science Initiative for Perfusion Imaging (OSIPI): ASL Pipeline inventory

Fan, H.; Mutsaerts, H. J. M. M.; Anazodo, U.; Arteaga, D.; Baas, K. P. A.; et al. (17 authors)

  • Open Access Logo Magnetic Resonance in Medicine 91(2024), 1787-1802
    Online First (2023) DOI: 10.1002/mrm.29869

Preparation of HOPO-containing lariate ethers based on the diaza-18-crown-6 scaffold

Paßler, F.; Belke, L.; Reissig, F.; Kopka, K.; Mamat, C.

2023

Combining Cisplatin with Different Radiation Qualities—Interpretation of Cytotoxic Effects In Vitro by Isobolographic Analysis

Runge, R.; Reissig, F.; Herzog, N.; Oehme, L.; Brogsitter, C.; et al. (6 authors)

Molecular imaging of bacterial outer membrane vesicles based on bacterial surface display

Szöllősi, D.; Hajdrik, P.; Tordai, H.; Horváth, I.; Veres, D. S.; et al. (25 authors)

Selecting active matter according to motility in an acoustofluidic setup: Self-propelled particles and sperm cells

Misko, V. R.; Baraban, L.; Makarov, D.; Huang, T.; Gelin, P.; et al. (10 authors)

Extended-gate field-effect transistor chemo- and biosensors: State of the art and perspectives

Janićijević, Ž.; Nguyen Le, T. A.; Baraban, L.

Preparation of 18F-Labeled Tracers Targeting Fibroblast Activation Protein via Sulfur [18F]Fluoride Exchange Reaction

Craig, A.; Kogler, J.; Laube, M.; Ullrich, M.; Donat, C.; et al. (8 authors)

The revision of the pharmaceutical legislation – it is time to act for nuclear medicine in Europe

Patt, M.; Decristoforo, C.; de Martini, A.; Koole, M.; Oyen, W.; et al. (6 authors)

Targeting colorectal cancer cells using AND-gated Adaptor RevCAR T-cells

González Soto, K. E.; Rodrigues Loureiro, L. R.; Bartsch, T.; Arndt, C.; Kegler, A.; et al. (16 authors)

Methods gold standard in clinic millifluidics multiplexed extended gate field-effect transistor biosensor with gold nanoantennae as signal amplifiers

Janićijević, Ž.; Nguyen Le, T. A.; Alsadig, A.; Cela, I.; Zilenaite, R.; et al. (9 authors)

Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment

Rodrigues Loureiro, L. R.; Hoffmann, L.; Neuber, C.; Rupp, L.; Arndt, C.; et al. (12 authors)

Bacterial filamentation mediates cross-protection against β-lactam antibiotics in droplet microreactors

Zhao, X.; Ruelens, P.; Farr, A. D.; de Visser, J. A. G. M.; Baraban, L.

Combination of tumor asphericity and an extracellular matrix-related prognostic gene signature in non-small cell lung cancer patients

Zschaeck, S.; Klinger, B.; van den Hoff, J.; Cegla, P.; Apostolova, I.; et al. (13 authors)

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents

Kubeil, M.; Suzuki, Y.; Casulli, M. A.; Kamal, R.; Hashimoto, T.; et al. (8 authors)

Bispidine Chelators for Radiopharmaceutical Applications with Lanthanide, Actinide and Main Group Metal Ions

Kopp, I.; Cieslik, P.; Anger, K.; Josephy, T.; Neupert, L.; et al. (15 authors)

Exploring Hydrophilic PD-L1 Radiotracers Utilizing Phosphonic Acids: Insights Into Unforeseen Pharmacokinetics

Krutzek, F.; Donat, C.; Stadlbauer, S.

Development of a Highly Specific 18F-labeled Radioligand for Imaging of Sigma-2 Receptor in Brain Tumor

Wang, T.; Wang, J.; Chen, L.; Zhang, X.; Mou, T.; et al. (11 authors)

Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients

Cegla, P.; Hofheinz, F.; Burchardt, E.; Czepczyński, R.; Kubiak, A.; et al. (10 authors)

18F-FDG PET/CT-derived total lesion glycolysis predicts abscess formation in patients with surgically confirmed infective endocarditis: Results of a retrospective study at a tertiary center

Maria Sag, S. J.; Menhart, K.; Hitzenbichler, F.; Schmid, C.; Hofheinz, F.; et al. (10 authors)

Radiomics predictive modeling from dual-time-point FDG PET Ki parametric maps: application to chemotherapy response in lymphoma

Samimi, R.; Shiri, I.; Ahmadyar, Y.; van den Hoff, J.; Kamali-Asl, A.; et al. (9 authors)

Design, Synthesis, and Biological Evaluation of Small Molecule Based Radioligands with Improved Pharmacokinetic Properties for Imaging of Programmed Death Ligand 1

Krutzek, F.; Donat, C.; Ullrich, M.; Stadlbauer, S.

Radiosynthesis and biological evaluation of [¹⁸F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in gliomas

Lai, T. H.; Wenzel, B.; Dukic-Stefanovic, S.; Teodoro, R.; Arnaud, L.; et al. (14 authors)

Equilibrium Thermodynamics of Macropa Complexes with Selected Metal Isotopes of Radiopharmaceutical Interest

Blei, M. K.; Waurick, L.; Reissig, F.; Kopka, K.; Stumpf, T.; et al. (8 authors)

Lysyl oxidases as targets for cancer therapy and diagnostic imaging

Löser, R.; Kuchar, M.; Wodtke, R.; Neuber, C.; Belter, B.; et al. (8 authors)

MRI-based parameter inference for cerebral perfusion modelling in health and ischaemic stroke

Jósza, T.; Petr, J.; Payne, S. J.; Mutsaerts, H.-J.

A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells

Kegler, A.; Drewitz, L.; Arndt, C.; Daglar, C.; Rodrigues Loureiro, L. R.; et al. (27 authors)

Synthesis and In Vitro Biological Evaluation of p-Carborane-based Di-tert-butylphenol Analogs

Braun, S.; Jelača, S.; Laube, M.; George, S.; Hofmann, B.; et al. (11 authors)

FLT3-directed UniCAR T-cell therapy of Acute Myeloid Leukaemia

Peschke, J.; Bergmann, R.; Mehnert, M.; González Soto, K. E.; Rodrigues Loureiro, L. R.; et al. (16 authors)

Design and Biological Evaluation of Small-Molecule PET-Tracers for Imaging of Programmed Death Ligand 1

Krutzek, F.; Donat, C.; Ullrich, M.; Zarschler, K.; Ludik, M.-C.; et al. (9 authors)

Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8

Ueberham, L.; Gündel, D.; Kellert, M.; Deuther-Conrad, W.; Ludwig, F.-A.; et al. (11 authors)

Radiofluorination of an anionic, azide-functionalized teroligomer by copper-catalyzed azide-alkyne cycloaddition

Wenzel, B.; Schmid, M.; Teodoro, R.; Moldovan, R.-P.; Lai, T. H.; et al. (11 authors)

Preclinical Characterization of the 177Lu-Labeled Prostate Stem Cell Antigen (PSCA)-Specific Monoclonal Antibody 7F5

Striese, F.; Neuber, C.; Gräßel, S.; Arndt, C.; Ullrich, M.; et al. (13 authors)

Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers

Pfeifer Serrahima, J.; Zhang, C.; Oberoi, P.; Bodden, M.; Röder, J.; et al. (13 authors)

Carborane-based Tebufelone Analogs and their Biological Evaluation In Vitro

Braun, S.; Paskas, S.; Laube, M.; George, S.; Hofmann, B.; et al. (11 authors)

Specific and safe targeting of glioblastoma using switchable and logic-gated RevCAR T cells

Abdelfatah Saleh Hassan, H. A.; Mitwasi, N.; Ullrich, M.; Kubeil, M.; Toussaint, M.; et al. (17 authors)

Isonimesulide and its carborane analogues as isoform-selective COX inhibitors and antitumor agents

Useini, L.; Komazec, T.; Laube, M.; Lönnecke, P.; Schädlich, J.; et al. (9 authors)

Comparative saturation binding analysis of ⁶⁴Cu-labeled somatostatin analogs using cell homogenates and intact cells

Ullrich, M.; Brandt, F.; Löser, R.; Pietzsch, J.; Wodtke, R.

Immunotargeting of Cancer Stem Cells.

Köseer, A. S.; Di Gaetano, S.; Arndt, C.; Bachmann, M.; Dubrovska, A.

High-Throughput Gel Microbeads as Incubators for Bacterial Competition Study

Nguyen Le, T. A.; Zhao, X.; Bachmann, M.; Ruelens, P.; de Visser, J. A. G. M.; et al. (6 authors)

Metastatic pheochromocytoma and paraganglioma: somatostatin receptor 2 expression, genetics and therapeutic responses

Fischer, A.; Kloos, S.; Maccio, U.; Friemel, J.; Remde, H.; et al. (33 authors)

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Kiß, O.; Scott, P.; Behe, M.; Penuelas, I.; Passchier, J.; et al. (21 authors)

Impedimetric Nanobiosensor for the Detection of SARS-CoV-2 Antigens and Antibodies

Sandoval Bojorquez, D. I.; Janićijević, Ž.; Palestina Romero, B.; Oliveros Mata, E. S.; Laube, M.; et al. (14 authors)

Strahlenschutzmaßnahmen bei der Anwendung von PET-Nukliden in der Krebsforschung

Wendler, M.; Kowe, S.

  • Strahlenschutz-Praxis 2(2023), 27-29
    ISSN: 0947-434 X

Genetic, vascular, and amyloid determinants of cerebral blood flow in a preclinical population

Padrela, B. E.; Lorenzini, L.; Collij, L. E.; Vállez García, D.; Coomans, E.; et al. (17 authors)

Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective

Moyaert, P.; Padrela, B.; Morgan, C.; Petr, J.; Versijpt, J.; et al. (15 authors)

Advanced MR Techniques for preoperative Glioma Characterization - Part 2

Hangel, G.; Schmitz-Abecassis, B.; Sollmann, N.; Pinto, J.; Arzanforoosh, F.; et al. (41 authors)

Advanced MR Techniques for preoperative Glioma Characterization - Part 1

Hirschler, L.; Sollmann, N.; Schmitz-Abecassis, B.; Pinto, J.; Arzanforoosh, F.; et al. (41 authors)

Nemacol is a Small Molecule Inhibitor of C. elegans Vesicular Acetylcholine Transporter with Anthelmintic Potential

Harrington, S.; Pyche, J.; Andrew, R. B.; Spalholz, T.; Ryan, K. T.; et al. (15 authors)

Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist’s perspective

Knieß, T.; Zessin, J.; Mäding, P.; Kuchar, M.; Kiß, O.; et al. (6 authors)

Cyclotron-based Production of 67Cu for Radionuclide Theranostics Via the 70Zn(p,α)67Cu Reaction

Brühlmann, S. A.; Walther, M.; Kreller, M.; Reissig, F.; Pietzsch, H.-J.; et al. (7 authors)

Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors

Bachmann, L. M.; Hanl, M.; Feller, F.; Sinatra, L.; Schöler, A.; et al. (8 authors)

Efforts towards PET-activatable red-shifted silicon rhodamines and silicon pyronine dyes

Kramer, C. S.; Kanagasundaram, T.; Matthias, J.; Kopka, K.

A convolutional neural network with self-attention for fully automated metabolic tumor volume delineation of head and neck cancer in [18F]FDG PET/CT

Nikulin, P.; Zschaeck, S.; Maus, J.; Cegla, P.; Lombardo, E.; et al. (20 authors)

Carborane Analogues of Fenoprofen Exhibit Improved Antitumor Activity

Useini, L.; Mojić, M.; Laube, M.; Lönnecke, P.; Mijatović, S. S.; et al. (8 authors)

The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2

Heerwig, A.; Kick, A.; Sommerfeld, P.; Eimermacher, S.; Hartung, F.; et al. (13 authors)

Effect of ISA and chloride on the uptake of niobium(V) by hardened cement paste and C-S-H phases: quantitative description and mechanistic understanding

Jo, Y.; Çevirim-Papaioannou, N.; Franke, K.; Fuss, M.; Pedersen, M.; et al. (9 authors)

In vitro Cytostatic Effect on Tumor Cells by Carborane-based Dual Cyclooxygenase-2 and 5-Lipoxygenase Inhibitors

Braun, S.; Paskas, S.; Laube, M.; George, S.; Hofmann, B.; et al. (11 authors)

Microdialysis reveals anti-inflammatory effects of sulfated glycosaminoglycanes in the early phase of bone healing

Schulze, S.; Neuber, C.; Möller, S.; Pietzsch, J.; Schaser, K.-D.; et al. (6 authors)

Interaction of Catalyst Nanoparticles and Pollutant Molecules in Photocatalytic Wastewater Treatment: Novel Characterization via Dynamic Surface Properties

Javadi, A.; Nourizade, M.; Rahmani, M.; Eckert, K.

Imaging of Gαq proteins in mouse and human organs and tissues

Voss, J. H.; Al-Hroub, H.; Gedschold, R.; Dietrich, J.; Gaffal, E.; et al. (13 authors)

Copper-free click bioconjugation of technetium-99m complexes using strained cyclononyne derivatives

Schlesinger, M.; Jentschel, C.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.

DGN-Handlungsempfehlung (S1-Leitlinie) PSMA-Liganden-PET/CT in der Diagnostik des Prostatakarzinoms Stand: 01/2022 AWMF-Registernummer: 031-055

Afshar-Oromieh, A.; Eiber, M.; Fendler, W.; Schmidt, M.; Rahbar, K.; et al. (18 authors)

Selective a3b4 nicotinic acetylcholine receptor ligand as a potential tracer for drug addiction

Kanasuwan, A.; Deuther-Conrad, W.; Sarasamkan, J.; Chotipanich, C.; Vajragupta, O.; et al. (6 authors)

Current state and Guidance on Arterial Spin Labeling Perfusion MRI in Clinical Neuroimaging

Lindner, T.; Bolar, D. S.; Achten, E.; Barkhof, F.; Bastos-Leite, A. J.; et al. (26 authors)

Improved protocol for the radiosynthesis of [18F]FTC-146: A potent and selective sigma-1 receptor radioligand

Sadeghzadeh, M.; Wenzel, B.; Nikodemus, J.; Florea, A.; Hertel, F.; et al. (9 authors)

  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 66(2023)3, 116-125
    DOI: 10.1002/jlcr.4018

Longitudinal and multimodal radiomics models for head-and-neck cancer outcome prediction

Starke, S.; Zwanenburg, A.; Leger, K.; Zöphel, K.; Kotzerke, J.; et al. (9 authors)

A self-assembled dynamic extracellular matrix-like hydrogel system with multi-scale structures for cell bioengineering applications

Xu, Y.; Rothe, R.; Voigt, D.; Sayed, A.; Huang, C.; et al. (13 authors)

Enzymological characterization of ⁶⁴Cu-labeled neprilysin substrates and their application for modulating the renal clearance of targeted radiopharmaceuticals

Brandt, F.; Ullrich, M.; Wodtke, J.; Kopka, K.; Bachmann, M.; et al. (9 authors)

Dipeptide-derived alkynes as potent and selective irreversible inhibitors of cysteine cathepsins

Behring, L.; Ruiz-Gomez, G.; Trapp, C.; Morales, M.; Wodtke, R.; et al. (10 authors)

Epigenetic drugs in somatostatin type 2 receptor radionuclide theranostics and radiation transcriptomics in mouse pheochromocytoma models

Ullrich, M.; Richter, S.; Liers, J.; Drukewitz, S.; Friedemann, M.; et al. (10 authors)

Synthesis, Structure–Activity Relationships, Radiofluorination, and Biological Evaluation of [18F]RM365, a Novel Radioligand for Imaging the Human Cannabinoid Receptor Type 2 (CB2R) in the Brain with PET

Teodoro, R.; Gündel, D.; Deuther-Conrad, W.; Toussaint, M.; Wenzel, B.; et al. (9 authors)

Anti-cancer prodrug cyclophosphamide exerts thrombogenic effects on human venous endothelial cells independent of CYP450 activation – relevance to thrombosis

Krüger-Genge, A.; Köhler, S.; Laube, M.; Haileka, V.; Lemm, S.; et al. (12 authors)

The value of arterial spin labelling perfusion MRI in brain age prediction

Dijsselhof, M.; Barboure, M.; Stritt, M.; Nordhøy, W.; Wink, A. M.; et al. (11 authors)

Calix[4]crowns with perfluoroalkylsulfonylcarboxamide functions: a complexation approach for heavy group 2 metal ions

Reissig, F.; Bauer, D.; Al-Ameed, K.; Luber, S.; Köckerling, M.; et al. (8 authors)

  • Open Access Logo Inorganic Chemistry Frontiers 10(2023), 370-382
    Online First (2022) DOI: 10.1039/d2qi01637k

Pages: [All] [1.] [2.] [3.] [4.] [5.] [6.] [7.] [8.] [9.] [10.] [11.] [12.] [13.] [14.]