Dose enhancement and localisation by combining reduced mass targets and a pulsed solenoid for radiobiological effectiveness studies of laser accelerated protons


Dose enhancement and localisation by combining reduced mass targets and a pulsed solenoid for radiobiological effectiveness studies of laser accelerated protons

Kroll, F.; Kluge, T.; Bussmann, M.; Cowan, T. E.; Herrmannsdörfer, T.; Kraft, S. D.; Metzkes, J.; Sauerbrey, R.; Schmidt, B.; Schramm, U.; Zeil, K.; Zier, M.; Zherlitsyn, S.

Abstract

Proton beams by means of the well-confined dose deposition in matter are a promising tool for improving radiotherapy of cancer. Wider clinical use, however, is limited by the complexity and expense of current proton accelerators. Compact laser-driven proton therapy accelerators are a potential alternative, yet require substantial development in reliable beam generation, transport and dosimetric monitoring as well as validation in radiobiological studies.

In vitro cell irradiations with laser-accelerated protons show radiobiological effectiveness similar to conventionally accelerated protons. In vivo animal irradiations – the next step in the translational research chain towards laser-driven proton therapy of cancer – are currently restricted by the low proton yield and energy at the irradiation site.

We report on systematic investigations of the ultrashort pulse laser-driven acceleration of protons from thin targets of narrow lateral dimension, so-called reduced mass targets (RMTs). A robust maximum energy enhancement (almost doubled) was found when compared to reference irradiations of plain foils of same thickness and material. Combining RMTs with a pulsed high-field solenoid for particle capturing, as developed at Helmholtz-Zentrum Dresden-Rossendorf, gives the potential to enhance and localise the dose per pulse applied to the tumour, thus making further radiobiological studies on volumetric tumours feasible in the future.

Involved research facilities

Related publications

  • Lecture (Conference)
    1st European Advanced Accelerator Concepts Workshop, 02.-07.06.2013, La Biodola, Elba, Italien

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