In-beam PET imaging for the control of heavy-ion tumour therapy.


In-beam PET imaging for the control of heavy-ion tumour therapy.

Pawelke, J.; Enghardt, W.; Haberer, T.; Hasch, B.-G.; Hinz, R.; Krämer, M.; Lauckner, K.; Sobiella, M.

Abstract

A method for the in-situ control of the heavy-ion tumour therapy by means of positron emission tomography is introduced. This method is founded on the measurement of the dynamic spatial distributions of beta+-emitters generated by nuclear fragmentation during the irradiation and their relation to the dose. In order to study this relationship and to derive the dose distribution from the measured beta+-activity distribution, a framework of model calculations is used. Results of phantom experiments with 12C ion beams will be presented, demonstrating good agreement between experiment and calculation as well as the possibilities and limits of the PET-technique for treatment plan verification and beam monitoring.

  • IEEE Transactions on Nuclear Science, Vol. 44, No. 4 (1997) 1492-1498
    DOI: 10.1109/23.632694
    Cited 86 times in Scopus
  • Lecture (Conference)
    IEEE Nuclear Science Symposium, 2-9 Nov, 1996, Anaheim, California, USA
    Conference Record, Vol. 2 (1996) 1099-1103
  • Contribution to proceedings
    IEEE Nuclear Science Symposium, 2-9 Nov, 1996, Anaheim, California, USA
    Conference Record, Vol. 2 (1996) 1099-1103

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