Cold denaturation of DNA origami nanostructures
Cold denaturation of DNA origami nanostructures
Dornbusch, D.; Hanke, M.; Tomm, E.; Grundmeier, G.; Keller, A.; Fahmy, K.; Kielar, C.
The coupling of structural transitions to heat capacity changes leads to destabilization of macromolecules at both, elevated and lowered temperatures. DNA origami not only exhibit this property but also provide a nanoscopic observable of cold denaturation processes by directing intramolecular strain to the most sensitive elements within their hierarchical architecture.
Keywords: protein unfolding; heat capacity; biopolymers; temperature dependence; self assembly; thermal stability
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Chemical Communications (2024)
Online First (2024) DOI: 10.1039/D3CC05985E
Permalink: https://www.hzdr.de/publications/Publ-37593