Pathological Biochemistry Group

The Pathological Biochemistry Group is concerned with elucidating the role of reactive oxygen species and other compounds in protein modification and damage. Particular emphasis is directed to the role of these processes in disorders such as atherosclerosis, rheumatoid arthritis, diabetes mellitus, and cancer.

Oxidative modification of proteins in vivo

The major aim is to obtain a better understanding of the mechanisms by which reactive oxygen species bring about protein modification (oxidation, glycoxidation etc.). The research interest of this group comprises the development of novel quantitative markers for the occurrence of protein modification and the down-stream effects of protein damage in human disease. A crucial role plays the development of novel methods for quantification of the metabolism of modified proteins in vivo, particularly, by employing small animal positron emission tomography studies(Concorde microPET P4). Besides these central projects the group is working in a number of projects on biochemical and radiopharmacological characterization of new radiotracers for both positron emission tomography and single photon emission tomography.

The research group has access to well-equipped and modern laboratories of the Positron Emission Tomography Center. There is a range of state of the art facilities for protein analysis, biochemical work, radioisotope work, cell isolation and culture, animal model studies, ultracentrifugation, chromatographic and mass spectrometric techniques(Equipment). Full training is provided in these methodologies. The group works closely with other laboratories in the Research Center Rossendorf, and has many active collaborations with major national and international groups. The group has good access to clinical materials through its close collaboration with Medical School Carl Gustav Carus at the University of Technology Dresden.

We are looking for motivated diploma students who want to work on the topics mentioned above. The precise thesis titles can be adapted to the interests and abilities of the applicants(Diploma and PhD Thesis). Your work will cover a broad range of biochemical and radiopharmaceutical methods. Applicants should possess a background in chemistry, biochemistry, or biology. Practical experience in basic techniques (e.g., how to prepare a buffer, how to use a pipette) is required.


PD Dr. Jens Pietzsch
Group leader
Mareike Barth